NIR-Light-Intensified Hypoxic Microenvironment for Cascaded Supra-Prodrug Activation and Synergistic Chemo/Photodynamic Cancer Therapy

Despite the fact that photodynamic therapy (PDT) has promising clinical prospects, its therapeutic efficacy is still restricted by hypoxic tumor microenvironment (TME). Therefore, how to suitably employ hypoxia vital for optimizing PDT. Herein we developed a hypoxia-activated prodrug combination with A hypoxia-responsive camptothecin (CPT)-based and near-infrared (NIR) BODIPY photosensitizer were coloaded within ?-cyclodextrin-based polymer through supramolecular host–guest recognition obtain nanoparticles named CPT-BODIPY-PNs. After being internalized tumor, oxygen in tissues was rapidly consumed moiety generate reactive species under NIR irradiation. The efficiently activated this intensified condition release chemotherapeutic CPT drug. This system makes best use of TME achieve effectively combined PDT chemotherapy, offering an approach cancer treatment.